Glutathione Bioavailability Study

Glutathione is an antioxidant that is naturally found in the body. Glutathione can help reduce cellular damage, minimize inflammation, and provide benefit to the skin. Natural glutathione concentration decreases naturally as we age, so supplementing with the antioxidant is common.

Study Objectives

To evaluate the absorption of a liposomal glutathione supplement compared to a non-liposomal (standard) glutathione supplement after seven consecutive days of administration.


The study was a two-group, randomized controlled trial.

  • Group A: Daily dose of 500mg of liposomal glutathione for seven consecutive days.
  • Group B: Daily dose of 500mg of standard glutathione for seven consecutive days.


Twenty healthy participants were enrolled in the study. They were randomly and evenly assigned to either Group A (liposomal supplementation) or Group B (standard supplementation). The participants were between the ages of 20-50 years old, did not have any chronic medical conditions, did not have any presence of acute illness, were within the normal BMI category (18.5-24.9 kg/m2), and did not use any drugs or dietary supplements on a frequent and/or mandatory basis.

Blood Sampling

Participants received their respective dosages of glutathione in the morning while fasting every day for seven days. Blood samples were collected at Baseline (Day 0), Day 3, and Day 7. Serum analysis tested for reduced glutathione (GSH) levels to identify absorption of supplements.


Results of this study show that liposomal glutathione supplementation has higher bioavailability than non-liposomal supplementation.

  • In the Liposomal Glutathione group, GSH concentration in the blood significantly increased from Baseline to Day 3, and from Day 3 to Day 7. 
  • There were no significant increases in GSH concentration for the non-liposomal group during the seven days.
  •  ActiNovo Liposomal Glutathione was found to be 64x more bioavailable than the standard Glutathione supplement.

Key Takeaways

  • Glutathione is a powerful antioxidant naturally produced by the body. Glutathione supplements are known to have very low bioavailability.
  • ActiNovo Liposomal Glutathione supplements have 64x more bioavailability than a standard Glutathione supplement over the course of 7 days.
  • Liposomal Glutathione supplementation was able to sustain a higher concentration of GSH in the blood over time than the standard supplement.

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